ROR gamma (t) Rat anti-Mouse, Clone: B2D, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-6981-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15257957

Quantity Price
1 £ 213.39 / 100µg
EU Stock 1
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Description and Specification

Specification

Applications Western Blot
Isotype IgG1
Conjugate Unlabeled
Host Species Rat
Concentration 0.5mg/mL
Species Reactivity Mouse
Gene Alias RORgamma, RORg, RORg(t), Retinoid-Related Orphan Receptor gamma
Storage Requirements Store at 2-8°C.
Regulatory Status RUO
Clone B2D
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 100μg
Antigen ROR gamma (t)
Monoclonal or Polyclonal Monoclonal
Format Purified

The B2D monoclonal antibody reacts with the mouse RORγ(t) protein. RORγ is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes RORα and RORβ. ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes. RORγ is expressed in several tissues including liver, lung, muscle, heart and kidney. Furthermore, it was discovered that alternative transcription results in the expression of an isoform, RORγt, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ “double-positive” thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoid organs.

The RORγt isoform differs from RORγ by three unique amino acids at the amino terminus. Therefore, the B2D antibody will react with both the RORγ and RORγt isoforms.