ROR gamma (t) Rat anti-Mouse, Clone: B2D, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-6981-82

100UG:ANTI-MOUSE ROR GAMMA (T) PURIFIED 100 UG

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15257957

Quantity Price
1 £ 213.39 / 100µg
Estimated Shipment date
from Supplier 28-02-2017
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Description and Specification

Specification

Gene Alias RORgamma, RORg, RORg(t), Retinoid-Related Orphan Receptor gamma
Host Species Rat
Applications Western Blotting
Isotype IgG1
Regulatory Status RUO
Species Reactivity Mouse
Storage Requirements Store at 2-8°C.
Clone B2D
Concentration 0.5mg/mL
Conjugate Unlabeled
Antigen ROR gamma (t)
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Quantity 100μg
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

The B2D monoclonal antibody reacts with the mouse RORγ(t) protein. RORγ is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes RORα and RORβ. ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes. RORγ is expressed in several tissues including liver, lung, muscle, heart and kidney. Furthermore, it was discovered that alternative transcription results in the expression of an isoform, RORγt, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ “double-positive” thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoid organs.

The RORγt isoform differs from RORγ by three unique amino acids at the amino terminus. Therefore, the B2D antibody will react with both the RORγ and RORγt isoforms.