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ROR gamma (t) Rat anti-Mouse, APC, Clone: B2D, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-6981-82

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15598176

  • £277.00 / 100µg

EU Stock 7

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Description

Description

Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. ROR gamma, a NR1 Thyroid Hormone-Like receptor, has been shown to affect thymopoiesis, bone metabolism, T-cell apoptosis, and lymphoid organogenesis. ROR gamma has been shown to promote thymocyte survival by activating the expression of the antiapoptotic protein Bcl-x(L). ROR gamma is also required for the development of lymph nodes and Peyer′s patches. It has been shown that ROR gamma t, a thymus-specific isoform of ROR gamma from mouse, inhibits Fas ligand expression and cytokine secretion in immature thymocytes. ROR gamma binds as a monomer to response elements composed of a single core motif, GGTCA, preceded by a 6 bp AT-rich sequence. ROR gamma expression has been documented in mouse thymus, adipose, bone, skeletal muscle, liver, and kidney, and in human skeletal muscle. ESTs have been isolated from human tissue libraries, including cancerous head/neck, germ cell, and prostate, and normal colon, head/neck, lung, liver/spleen, and pancreas.
Specifications

Specifications

ROR gamma (t)
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P51450
MGC129539; NR1F3; RORG; RZR-GAMMA; RZRG; TOR; RORgt
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
B2D
APC
Rorc
Liquid
Rorc
IgG1, kappa
100 μg
4° C, store in dark, DO NOT FREEZE!
Primary
19885
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