ROR gamma (t) Rat anti-Human, Mouse, Clone: AFKJS-9, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-6988-80

Product Code. 15267957

Disclaimers:

For Research Use Only.

Description

The AJKJS-9 monoclonal antibody reacts with the mouse RORγ(t) protein. RORγ is a member of the retinoic acid-related orphan receptor (ROR) family, which also includes RORα and RORβ. ROR family proteins are ligand-dependent transcription factors that play roles in multiple physiological processes. RORγ is expressed in several tissues including liver, lung, muscle, heart and kidney. Furthermore, it was discovered that alternative transcription results in the expression of an isoform, RORγt, which is expressed exclusively in cells of the lymphoid compartment, namely CD4+CD8+ “double-positive” thymoyctes, Th17 cells of the periphery and lymphoid tissue inducer (Lti) cells of lymphoid organs.

The RORγt isoform differs from RORγ by three unique amino acids at its amino terminus. Therefore, the AFKJS-9 antibody will react with both the RORγ and RORγt isoforms.

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Specifications

• Antigen: ROR gamma (t)
• Clone: AFKJS-9
• Conjugate: Unlabeled
• Format: Purified
• Host Species: Rat
• Quantity: 25μg
• Storage Requirements: Store at 2-8°C.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Western Blot
• Concentration: 0.5mg/mL
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Gene Alias: Retinoid-Related Orphan Receptor gamma
• Isotype: IgG2a
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Murine