Tocris Bioscience™ Ro 25-6981 maleate

GluN2B-selective NMDA antagonist

Description

Potent and selective activity-dependent blocker of NMDA receptors containing the GluN2B (formally NR2B) subunit. IC50 values are 0.009 and 52 μM for cloned receptor subunit combinations GluN1C/GluN2B and GluN1C/GluN2A respectively. Displays neuroprotectant effects in vivo and in vitro.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Specifications

• Chemical Name or Material: (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate
• Assay Percent Range: >98%
• Molecular Formula: C₂₂H₂₉NO₂.C₄H₄O₄

• CAS: 1312991-76-6
• Solubility: Soluble to 100mM in DMSO
• Formula Weight: Observed MW: 455.55

For Research Use Only