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Invitrogen™ MMP8 Rat ELISA Kit

Sandwich ELISA Kit

Brand:  Invitrogen™ ERMMP8

Code : NEW

Additional Details : Weight : 0.33000kg

Product Code. 15495383

  • £398.00 / 1 set


Estimated Shipment date
from Supplier 22-06-2020
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Includes: Pre-coated plate(s), standard, detector antibody, HRP conjugate, diluents, wash buffer, chromogen, stop solution, and plate covers.

Description

Description

Matrix Metalloproteinase 8 (MMP8) is also known as neutrophil collagenase and collagenase 2. MMP8 degrades fibrillar collagens types I, II, III, aggrecan, serpins and alpha 2 macroglobulin. All collagenases cleave fibrillar collagens at one specific site resulting in generation of N-terminal three-quarter and C-terminal one-quarter fragments, which then denature to gelatin at body temperature. The substrate specificity of collagenases is variable: MMP1 degrades type III collagen more efficiently than type I or type II collagen, whereas MMP8 is more potent in degrading type I collagen than type III or type II collagen. MMP13, in turn degrades type II collagen 6-fold more efficiently than type I and type II collagens and displays almost 50-fold stronger gelatinolytic activity than MMP1 and MMP8. MMP8 is very similar to MMP1, sharing 57 % amino acid identity. Most cell types do not produce MMP8. Until recently, it was thought that MMP8 was produced exclusively by neutrophils, but it has also been detected in other cell types including arthritic chondrocytes and gingival fibroblasts. The human MMP8 gene has the chromosomal location of 11q22.2-22.3.
Specifications

Specifications

O88766
HRP
50pg/mL to 40 ng/ml
ELISA, Protein Assays, Protein Biology, Cancer Biology, Immunology, Neuroscience, Neurobiology, Protein Detection, Protein Analysis
Pre-coated 96 well plate, Standard, Assay Diluent concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
RUO
100 μL per sample after dilution
This ELISA kit shows no cross-reactivity with the following cytokines tested: rat CINC-2, CINC-3, CNTF, Fractalkine, IL-1 alpha, IL-1 beta, IL-4, IL-6, IL-10, GM-CSF, IFN-gamma, Leptin, Lix, MCP-1, MIP-3 alpha, beta- NGF, TIMP-1, TNF-alpha.
96 assays
4 hr. 45 min.
Solid-phase sandwich ELISA
Other Research
<12%
96 Tests
Supernatant
Colorimetric Microplate Reader
0.05-40 ng/mL
Biotin
63849
ELISA Kit
50 pg/mL
Plasma, 1 μL|Serum, 1 μL|Supernatant, 100 μL
2°C to 8°C
1 hr. 20 min.
Rat
Proteases, Peptidases & Inhibitors
Mmp8
<10%
Rat
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