R&D Systems™ Z-Leu-Leu-Leu-B(OH)2 (MG-262)

Highly potent and selective cell-permeable inhibitor of the proteasome

Description

• This peptide boronic acid is structurally similar to the peptide aldehyde MG-132 and also inhibits the chymotrypsin-like peptidase activity of the proteasome, but with much higher potency
• These inhibitors are reversible and also inhibit the activity of calpains and cathepsins
• Purity >95% by HPLC
• Structure confirmed by 1H-NMR