missing translation for 'onlineSavingsMsg'
Learn More

PU.1 Mouse anti-Human, Mouse, Clone: phpu13, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9819-80

UNSPSC : 12352200

Code : Z2

Additional Details : Weight : 0.01000kg

 View more versions of this product

Product Code. 15248187

  • £55.59 / 25µg


Call for latest availability
+44 (0)1509 555 500
Add to basket

Disclaimers:

For Research Use Only.


Specifications

Description

The monoclonal phpu13 recognizes human and mouse PU.1, a member of the ets family of transcription factors. This 42kDa protein was originally identified as Spi-1, a proto-oncogene, for its role in Friend virus-induced murine erythroleukemia. Expression of PU.1 plays a critical role in lymphocyte and myeloid development. Knock-out mice are neonatal lethal and lack myeloid, T and B cells. In addition erythroid development is also altered. Protein expression levels help guarantee proper development; higher levels in myeloid cells compared to lymphocytes. PU.1 controls transcription of several proteins including CD11b, CD18, Gata2, IRF4, CD20, CD10, and CD79.

Disruption of PU.1 expression may play a role in several specific leukemias; such as B-chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, and nodular lymphocyte predominant Hodgkin.
Description & Specifications

Specifications

PU.1
phpu13
Unlabeled
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
IgG1
RUO
Primary
Murine
Immunohistochemistry (Formalin/Paraffin)
0.5mg/mL
Purified
Murine
25μg
Store at 2-8°C.
Monoclonal