Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM) Mouse, Clone: 12E3, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9118-82

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg



Disclaimers: For Research Use Only.

Product Code. 15527586

Quantity Price
1 £ 149.04 / 100µg
EU Stock 3
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Isotype IgM
Antigen Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM)
Host Species Mouse
Primary or Secondary Primary
Species Reactivity Human, Mouse, Rat
Conjugate Unlabeled
Storage Requirements Store at 2-8°C.
Regulatory Status RUO
Clone 1.20E+04
Quantity 100μg
Concentration 0.5mg/mL
Format Purified
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer

The monoclonal antibody 12E3 specifically recognizes polysialylated neural cell adhesion molecule (PSA-NCAM) in human, mouse and rat. Polysialic acid is a long homopolymer of sialic acid that is negatively charged and is attached to neural cell adhesion molecule (CD56) and serves as a regulator of NCAM function. PSA attachment to NCAM is associated with inhibited adhesion of neural cells. PSA-NCAM expression is highly regulated and corresponds to specific neural developmental windows in which neural precursors are migrating and during the process of axonal sprouting, guidance, and targeting. PSA-NCAM expression is prevalent during development of the brain, but in the adult becomes restricted to regions undergoing self-renewal or exhibiting plasticity such as the olfactory bulb, suprachiasmatic nucleus, hippocampus, hypothalamus, and specific spinal cord nuclei. PSA-NCAM is re-expressed during tumorigenesis and is also expressed on cell lines isolated from neuroblastomas and pheochromocytomas.