Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM) Mouse, Clone: 12E3, eBioscience™

Mouse Monoclonal Antibody

Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9118-80

Code: NEW

Additional Details:
Additional Details: Weight: 0.09500kg

Disclaimers: For Research Use Only.

Product Code. 15517586

Quantity Price
1 £ 61.7 / 25µg
EU Stock 1
Add to basket

Description and Specification


Quantity 25μg
Format Purified
Clone 1.20E+04
Applications Immunocytochemistry
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunohistochemistry (Frozen)
Applications Microscopy
Conjugate Unlabeled
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Storage Requirements Store at 2-8°C.
Monoclonal or Polyclonal Monoclonal
Concentration 0.5mg/mL
Regulatory Status RUO
Species Reactivity Human, Mouse, Rat
Isotype IgM
Host Species Mouse
Primary or Secondary Primary
Antigen Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM)

The monoclonal antibody 12E3 specifically recognizes polysialylated neural cell adhesion molecule (PSA-NCAM) in human, mouse and rat. Polysialic acid is a long homopolymer of sialic acid that is negatively charged and is attached to neural cell adhesion molecule (CD56) and serves as a regulator of NCAM function. PSA attachment to NCAM is associated with inhibited adhesion of neural cells. PSA-NCAM expression is highly regulated and corresponds to specific neural developmental windows in which neural precursors are migrating and during the process of axonal sprouting, guidance, and targeting. PSA-NCAM expression is prevalent during development of the brain, but in the adult becomes restricted to regions undergoing self-renewal or exhibiting plasticity such as the olfactory bulb, suprachiasmatic nucleus, hippocampus, hypothalamus, and specific spinal cord nuclei. PSA-NCAM is re-expressed during tumorigenesis and is also expressed on cell lines isolated from neuroblastomas and pheochromocytomas.