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PSA-NCAM, clone: 12E4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 14-9118-80

Code : NEW

Additional Details : Weight : 0.09500kg

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Product Code. 15517586

  • £63.55 / 25µg


EU Stock 1
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Description

Description

Description: The monoclonal antibody 12E3 specifically recognizes polysialylated neural cell adhesion molecule (PSA-NCAM) in human, mouse and rat. Polysialic acid is a long homopolymer of sialic acid that is negatively charged and is attached to neural cell adhesion molecule (CD56) and serves as a regulator of NCAM function. PSA attachment to NCAM is associated with inhibited adhesion of neural cells. PSA-NCAM expression is highly regulated and corresponds to specific neural developmental windows in which neural precursors are migrating and during the process of axonal sprouting, guidance, and targeting. PSA-NCAM expression is prevalent during development of the brain, but in the adult becomes restricted to regions undergoing self-renewal or exhibiting plasticity such as the olfactory bulb, suprachiasmatic nucleus, hippocampus, hypothalamus, and specific spinal cord nuclei. PSA-NCAM is re-expressed during tumorigenesis and is also expressed on cell lines isolated from neuroblastomas and pheochromocytomas.Applications Reported: This 12E3 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, and immunocytochemistry.Applications Tested: This 12E3 antibody has been tested by immunocytochemistry of formaldehyde-fixed PC-12 (rat) cells and can be used at less than or equal to 20 μg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Purity: Greater than 90%, as determined by SDS-PAGE.Aggregation: Less than 10%, as determined by HPLC.Filtration: 0.2μm post-manufacturing filtered.
Specifications

Specifications

Polysialylated Neural Cell Adhesion Molecule (PSA-NCAM)
Monoclonal
0.5mg/mL
PBS with 0.09% sodium azide; pH 7.2
P13591, P13595, P13596
CD56, NCAM1, Neural cell adhesion molecule 1, NCAM-1, Polysialylated-neural cell adhesion molecule, Polysialylated NCAM, PSA NCAM
Murine
Affinity chromatography
RUO
Antibody
Monoclonal
HumanþMurineþRat
ImmunocytochemistryþImmunohistochemistryþImmunohistochemistry (Frozen)þMicroscopy
1.20E+04
Unconjugated
NCAM1
Purified
NCAM1
IgM
25μg
Store at 2-8°C.
Primary
4684
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