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Podoplanin Rat anti-Human, Clone: NZ-1.3, eBioscience™

Rat Monoclonal Antibody

£104.00 - £240.00

Specifications

Antigen Podoplanin
Clone NZ-1.3
Target Species Human
Conjugate Unconjugated
Isotype IgG2a
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15248167
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Affymetrix eBioscience
14-9381-80
25 μg
£104.00
25µg
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Estimated Shipment
08-12-2020
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15258167
View Documents
Affymetrix eBioscience
14-9381-82
100 μg
£240.00
100µg
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»
In stock, ready to ship: 3 Please to purchase this item. Need a web account? Register with us today!
Description

Description

Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
Specifications

Specifications

Podoplanin
Human
IgG2a
Monoclonal
Liquid
Antibody
4° C
NZ-1.3
Unconjugated
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Primary
Monoclonal
PBS with 0.09% sodium azide; pH 7.2
RUO
SDS

For Research Use Only.