Podoplanin Rat anti-Human, Clone: NZ-1.3, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9381-82

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15258167

Quantity Price
1 £ 140.02 / 100µg
Estimated Shipment date
from Supplier 04-05-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human
Antigen Podoplanin
Concentration 0.5mg/mL
Gene Alias PDPN
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Host Species Rat
Regulatory Status RUO
Storage Requirements Store at 2-8°C.
Quantity 100μg
Conjugate Unlabeled
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Isotype IgG2a
Clone NZ-1.3
Format Purified

Podoplanin is a 40kDa type I transmembrane sialomucin-like glycoprotein involved in platelet aggregation and cancer metastasis. This protein is expressed on lymphatic endothelial cells and follicular dendritic cells, as well as on many human cancers, including squamous cell carcinoma, glioblastoma, seminoma, and mesothelioma. Podoplanin expression has been demonstrated to be regulated by the Fos protein of the Activating Protein-1 (AP-1) transcription factor complex. Much of its functionality arises via interaction with its endogenous receptor, C-type lectin-like receptor-2 (CLEC-2).

This antibody has been reported to block the interaction between Podoplanin and CLEC-2.