Podoplanin Rat anti-Human, Clone: NZ-1.3, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-9381-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15248167

Quantity Price
1 £ 66.65 / 25µg
EU Stock 4
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Description and Specification

Specification

Format Purified
Isotype IgG2a
Quantity 25μg
Antigen Podoplanin
Applications Immunohistochemistry (Formalin/Paraffin)
Applications Immunoprecipitation
Applications Western Blotting
Regulatory Status RUO
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Concentration 0.5mg/mL
Gene Alias PDPN
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Conjugate Unlabeled
Host Species Rat
Clone NZ-1.3
Storage Requirements Store at 2-8°C.

Podoplanin is a 40kDa type I transmembrane sialomucin-like glycoprotein involved in platelet aggregation and cancer metastasis. This protein is expressed on lymphatic endothelial cells and follicular dendritic cells, as well as on many human cancers, including squamous cell carcinoma, glioblastoma, seminoma, and mesothelioma. Podoplanin expression has been demonstrated to be regulated by the Fos protein of the Activating Protein-1 (AP-1) transcription factor complex. Much of its functionality arises via interaction with its endogenous receptor, C-type lectin-like receptor-2 (CLEC-2).

This antibody has been reported to block the interaction between Podoplanin and CLEC-2.