Thermo Scientific™ Pierce™ Sulfo-NHS Crosslinker

Prepare amine-reactive sulfo-NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysulfosuccinimide, CAS 106627-54-7.

Brand: Thermo Scientific™

Manufacturer Part Number: 24525


UNSPSC: 12161502

Code: PN

Additional Details:
Additional Details: CAS Number: 63038-44-8 Weight: 0.45360kg

Product Code. 11871365

Quantity Price
1 £ 1144.0 / 5g
EU Stock 48
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Description and Specification


Chemical Reactivity Carboxyl-to-Amine
Description Pierce Sulfo-NHS
Formulation N-Hydroxysulfosuccinimide; powder solid
Membrane Permeable Yes
Molecular Weight 217.13
PEGylated No
Quantity 5g
Sufficient For 4605mL of typical 1X (5mM) reaction solution, or approx. 2500 uses at 2mg reagent per use
Spacer Arm Length
Storage Requirements Store as detailed on product information sheet.
Water Soluble Yes


  • Forms an acyl amino ester with carboxyl groups when used with the EDC
  • Sulfo-NHS-activated molecule reacts efficiently with primary amines, resulting in stable amide bond
  • Allows for two-step EDC reactions between carboxyl- and amine-containing molecules
  • Sulfo-NHS-activated molecule can be stabilized by drying, allowing manufacture of amine-reactive probes and surfaces
  • Reactive groups: Sulfo-NHS
  • Reactive toward: amino groups (upon activation of carboxylates)