Thermo Scientific™ Pierce™ Sulfo-NHS Crosslinker

Prepare amine-reactive sulfo-NHS-ester crosslinkers or enhance carbodiimide (EDC) conjugation for peptides or proteins using N-hydroxysulfosuccinimide, CAS 106627-54-7.

Brand: Thermo Scientific™

Manufacturer Part Number: 24525

UNSPSC: 12161502

Code: PN

Additional Details:
Additional Details: CAS Number: 63038-44-8 Weight: 0.45360kg

Product Code. 11871365

Quantity Price
1 £ 1144.0 / 5g
EU Stock 45
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Description and Specification


Storage Requirements Store as detailed on product information sheet.
Formulation N-Hydroxysulfosuccinimide; powder solid
Molecular Weight 217.13
Sufficient For 4605mL of typical 1X (5mM) reaction solution, or approx. 2500 uses at 2mg reagent per use
Spacer Arm Length
Description Pierce Sulfo-NHS
Membrane Permeable Yes
Chemical Reactivity Carboxyl-to-Amine
PEGylated No
Quantity 5g
Water Soluble Yes


  • Forms an acyl amino ester with carboxyl groups when used with the EDC
  • Sulfo-NHS-activated molecule reacts efficiently with primary amines, resulting in stable amide bond
  • Allows for two-step EDC reactions between carboxyl- and amine-containing molecules
  • Sulfo-NHS-activated molecule can be stabilized by drying, allowing manufacture of amine-reactive probes and surfaces
  • Reactive groups: Sulfo-NHS
  • Reactive toward: amino groups (upon activation of carboxylates)