Thermo Scientific Pierce™ Premium Grade Sulfo-NHS

Optimize applications where product integrity and risk minimization are paramount with our highest quality formulation of this N-hydroxysuccinimide modification reagent.

Brand: Thermo Scientific

Manufacturer Part Number: PG82071


UNSPSC: 12161502

Code: NEW

Additional Details:
Additional Details: Weight: 0.01000kg

Product Code. 15215763

Quantity Price
1 £171.37 / 500mg
EU Stock 4
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Description and Specification


Formulation N-Hydroxysulfosuccinimide; powder solid
Quantity 500mg
Sufficient For 0.46L of typical 1X (5mM) reaction solution

Thermo Scientific Pierce Premium Grade Sulfo-NHS is our highest quality formulation of this N-hydroxysuccinimide chemical modification reagent, specially characterized for applications where product integrity and risk minimization are paramount.

Compared to the standard grade product, Premium Grade Sulfo-NHS provides more clearly defined quality and product support by including (a) increased analytical testing and product characterization, (b) greater batch-specific information and quality assurance review, (c) extensive lot sample retention and (d) change control notification. Sulfo-NHS (N-hydroxysulfosuccinimide) enables control and modification of carbodiimide crosslinking reactions involving activation of carboxylates (–COOH) for conjugation with primary amines (–NH2). Derivatives are easily synthesized by mixing the sulfo-NHS with a carboxyl-containing molecule and a dehydrating agent such as the carbodiimide EDC (EDAC). The method is the basis for generating many types of protein labeling reagents, including amine-reactive fluorescent dyes, biotin affinity tags and pegylation compounds.


  • Sulfo-NHS – use with EDC crosslinker to prepare amine-reactive NHS ester reagents
  • High quality – identity and purity confirmed by several tests, including quantitative NMR
  • Product integrity – enhanced level of testing and characterization compared to standard grade
  • Lot retention – ample supply of past lots retained to ensure future process testing
  • Change management – Change Control Notification (CCN) service
  • Consistent manufacture – batch-specific manufacturing documentation review


  • Improve efficiency of EDC coupling reactions
  • Convert carboxyls to amine-reactive sulfo-NHS esters
  • Membrane-impermable for cell surface labeling
  • Crosslink proteins to carboxyl-coated beads or surfaces more efficiently
  • Activate nanoparticles with amine-reactive sulfo-NHS esters