Thermo Scientific™ Pierce™ DSS Crosslinker

Crosslink amines to amines with disuccinimidyl suberate composed of NHS-ester groups with a membrane-permeable, mid-length spacer for intracellular protein crosslinking.

Brand: Thermo Scientific™

Manufacturer Part Number: 21658


UNSPSC: 12161502

Code: A0

Additional Details:
Additional Details: Weight: 0.80000kg Transport: UN number : 3261 Chem class : 1a Pack group : III

Product Code. 11831255

Quantity Price
1 £63.00 / Pack of 8
EU Stock 15
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Description and Specification


Chemical Reactivity Amine-to-Amine
Cleavable No
Description Pierce DSS
Formulation Disuccinimidyl suberate; powder solid
Membrane Permeable Yes
Molecular Weight 368.34
PEGylated No
Quantity 8 x 2mg
Sufficient For 43mL of typical 1X (1mM) reaction solution (total), or 8 separate uses
Spacer Arm Length 11.4Å
Water Soluble No


  • Chemical crosslinking of intracellular proteins prior to cell lysis and immunoprecipitation
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Crosslink oriented antibodies to Protein A or G agarose
  • Immobilize proteins onto amine-coated surfaces


Technical documents