The Competition RED Device was developed in association with pharmaceutical laboratories to more accurately model in vivo drug interactions by enabling equilibrium dialysis experiments to be performed in a multiplexed format involving competition for binding among different tissues. The system consists of disposable dialysis tube inserts and a reusable base plate made of high-grade PTFE. The Competition Base Plate is much like our regular RED Device Base Plate except that it is divided into different size chambers (wells) for positioning 2 to 8 RED Device Inserts per well. The format enables competitive dialysis experiments involving 2 to 15 separate tissue or protein fluid samples. Each Competition RED Insert contains either one or two separate dialysis chambers (each package includes a selection of both types). The Competition RED Device requires no extensive assembly or specialized equipment, and each chamber/well is easily accessible from the top of the device.
Easy to use – disposable tubes require no presoaking step, assembly, or specialized equipment
Short incubation time – design provides high surface-to-volume ratio of membrane to sample, enabling equilibrium to be reached within 2 to 4 hours
Flexible format – base plate contains several different chamber sizes, enabling small molecule partitioning studies involving 2 to 16 tissue or protein samples without waste
Robust – compartmentalized design eliminates potential for cross-talk or leakage
Reproducible and accurate – perform controlled experiments with multiple tissues to obtain screening results that have high predictability for in vivo studies with animal models
Validated quality – base plate is composed of chemically inert high-grade PTFE, eliminating non-specific binding and risk of contamination; each lot is functionally tested in a protein binding assay for guaranteed performance
ADME-Tox studies for in vitro screening of drug partitioning between plasma and multiple tissues before in vivo experiments with animal models; Aids in determining formulation of drug dosage for in vivo studies; Drug-drug interaction studies; Competitive binding and dissociation constant determination for small molecules versus multiple targets