Thermo Scientific™ Pierce™ CHAPS

Non-denaturing Zwitterionic detergents that disrupt nonspecific protein interactions with less protein aggregation than nonionic detergents.

Brand: Thermo Scientific™

Manufacturer Part Number: 28300

UNSPSC: 41116111

Code: PN

Additional Details:
Additional Details: CAS Number: 2446-83-5 Weight: 0.80000kg

Product Code. 11851445

Quantity Price
1 £ 127.0 / 5g
EU Stock 11
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Description and Specification


Formulation 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
Properties Zwitterionic, Dialyzable
Description CHAPS
Quantity 5g

CHAPS is a sulfobetaine derivatives of cholic acid. This zwitterionic detergent is useful for membrane protein solubilization when it is important to maintain protein activity. CHAPS detergent is soluble over a wide range of pH (2 to 12) and are easily removed from solution by dialysis because of their high critical micelle concentration (CMC).


  • Versatile zwitterionic detergents
  • Provide mild but effective lysis of cultured mammalian cells
  • Nondenaturing and generally do not inactivate protein functions
  • Can be removed from solution by dialysis
  • Commonly used for isoelectric focusing (IEF) and 2D electrophoresis

Properties of CHAPS detergent:

  • Chemical Name: 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
  • Molecular Weight: 614.88
  • Detergent Class: Zwitterionic
  • Aggregation Number: 10
  • Micelle Molecular Weight: 6149
  • Critical Micelle Concentration (CMC): 8 to 10mM (0.4920 to 0.6150%, w/v)
  • Cloud Point: ≥ 100°C
  • Dialyzable: Yes