Thermo Scientific™ Pierce™ BS3 (Sulfo-DSS) Crosslinker

Crosslink amines to amines with BS3; composed of sulfo-NHS-ester groups separated by an 11.4A, water-soluble spacer arm that is useful for cell-surface protein crosslinking.

Brand: Thermo Scientific™

Manufacturer Part Number: 21585

UNSPSC: 12161502

Code: PN

Additional Details:
Additional Details: Weight: 1.81440kg

Product Code. 11841245

Quantity Price
1 £ 110.0 / Pack of 8
EU Stock 46
Add to basket

Description and Specification


Spacer Arm Length 11.4Å
Formulation Bis(sulfosuccinimidyl) suberate; solid
Cleavable No
Molecular Weight 572.43
Sufficient For 28mL of typical 1X (1mM) reaction solution (total), or 8 separate uses
Description Pierce BS3 (Sulfo-DSS), No-Weigh Format
Membrane Permeable No
Chemical Reactivity Amine-to-Amine
PEGylated No
Quantity 8 x 2mg
Water Soluble Yes


  • Crosslink cell-surface proteins before cell lysis and immunoprecipitation
  • Identify receptor-ligand interactions by chemical crosslinking
  • “Fix” protein interactions to allow identification of weak or transient protein interactions
  • Identify near-neighbor protein interactions
  • Protein crosslinking to create bioconjugates via single-step reactions
  • Immobilize proteins onto amine-coated surfaces


Technical documents