Phospho-SYK (Y348) Mouse anti-Human, Mouse, APC, Clone: moch1ct, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-9014-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15578216

Quantity Price
1 £ 188.93 / 100 tests
Estimated Shipment date
from Supplier 09-05-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen Phospho-SYK (Y348)
Concentration 5μL (0.06μg)/test
Gene Alias Spleen tyrosine kinase, p72-Syk
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry (Intracellular Staining)
Isotype IgG1
Conjugate APC
Format Conjugated
Clone moch1ct
Species Reactivity Human, Mouse
Primary or Secondary Primary
Quantity 100 tests
Host Species Mouse
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.

This moch1ct monoclonal antibody recognizes human and mouse spleen tyrosine kinase (also known as SYK) when phosphorylated on tyrosine 348 (Y348). SYK is the founding member of the SYK family of kinases that also includes ZAP-70 (zeta-associated protein of 70 kD) and is expressed in hematopoietic cells, including B lymphocytes, immature (CD4, CD8 double-negative and double-positive) thymocytes, and myeloid cells, epithelial cell lines, and normal breast tissue. SYK is critical for B cell receptor (BCR) signaling and B cell development. Autophosphorylation of at Y348 is necessary for SYK to become fully catalytically active and creates a docking site for the SH2 domains of Vav, Grb2, p85 subunit of PI3 kinase, and PLC gamma.

Specificity of this moch1ct clone was confirmed by ELISA, flow cytometry, and western blotting.