Phospho-STAT5 (Y694) Mouse anti-Human, Mouse, PerCP-eFluor 710, Clone: SRBCZX, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 46-9010-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15569386

Quantity Price
1 £ 91.11 / 25 tests
Estimated Shipment date
from Supplier 10-05-2017
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Description and Specification

Specification

Gene Alias signal transducer and activator of transcription 5, pSTAT5
Concentration 5μL (0.06μg)/test
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Host Species Mouse
Species Reactivity Human, Mouse
Monoclonal or Polyclonal Monoclonal
Quantity 25 tests
Isotype IgG1
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Antigen Phospho-STAT5 (Y694)
Regulatory Status RUO
Primary or Secondary Primary
Format Conjugated
Conjugate PerCP-eFluor 710
Clone SRBCZX
Applications Flow Cytometry (Intracellular Staining)

This SRBCZX monoclonal antibody recognizes signal transducer and activator of transcription 5 (STAT5) when phosphorylated on tyrosine 694. STAT proteins are activated by ligand binding to receptors, such as cytokine receptors, that associate with Janus kinase (JAK) family members. Following their phosphorylation by JAKs, STAT proteins translocate to the nucleus where they bind to DNA and regulate transcription of specific genes in a cell type- and cytokine-specific manner. In response to cytokines that signal through the common gamma chain such as IL-2, IL-7, and IL-15, STAT5 is phosphorylated on tyrosine 694 by JAK1 and JAK3. Cytokines such as IL-3, IL-5, and GM-CSF that signal via the common beta chain induce STAT5 phosphorylation on tyrosine 694 by JAK 2. Phosphorylation of STAT5 on tyrosine 694 is essential for STAT5 dimer formation, nuclear translocation, and DNA binding activity.

Specificity of this SRBCZX clone was determined by ELISA and flow cytometry.