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Phospho-STAT5 (Y694) Mouse anti-Human, Mouse, PerCP-eFluor 710, Clone: SRBCZX, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-9010-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15579386

  • £219.50 / 100 tests


Estimated Shipment date
from Supplier 29-09-2017
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Disclaimers:

For Research Use Only.


Description

Description

This SRBCZX monoclonal antibody recognizes signal transducer and activator of transcription 5 (STAT5) when phosphorylated on tyrosine 694. STAT proteins are activated by ligand binding to receptors, such as cytokine receptors, that associate with Janus kinase (JAK) family members. Following their phosphorylation by JAKs, STAT proteins translocate to the nucleus where they bind to DNA and regulate transcription of specific genes in a cell type- and cytokine-specific manner. In response to cytokines that signal through the common gamma chain such as IL-2, IL-7, and IL-15, STAT5 is phosphorylated on tyrosine 694 by JAK1 and JAK3. Cytokines such as IL-3, IL-5, and GM-CSF that signal via the common beta chain induce STAT5 phosphorylation on tyrosine 694 by JAK 2. Phosphorylation of STAT5 on tyrosine 694 is essential for STAT5 dimer formation, nuclear translocation, and DNA binding activity.

Specificity of this SRBCZX clone was determined by ELISA and flow cytometry.
Specifications

Specifications

Phospho-STAT5 (Y694)
SRBCZX
PerCP-eFluor 710
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.06μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
signal transducer and activator of transcription 5, pSTAT5
IgG1
RUO
Primary
Murine