Phospho-Src (Y418) Mouse anti-Human, Mouse, PE, Clone: SC1T2M3, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9034-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15537166

Quantity Price
1 £ 188.93 / 100 tests
Estimated Shipment date
from Supplier 08-05-2017
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Description and Specification

Specification

Conjugate PE
Host Species Mouse
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone SC1T2M3
Species Reactivity Human, Mouse
Monoclonal or Polyclonal Monoclonal
Isotype IgG2b
Format Conjugated
Primary or Secondary Primary
Concentration 5μL (0.25μg)/test
Antigen Phospho-Src (Y418)
Gene Alias ASV, c-src, c-SRC, p60-Src, pp60c-src, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, SRC1
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Quantity 100 tests

This SC1T2M3 monoclonal antibody recognizes human and mouse Src tyrosine kinase (also known as ASV, c-src, c-SRC, p60-Src, pp60c-src, Proto-oncogene c-Src, Proto-oncogene tyrosine-protein kinase Src, SRC1) when phosphorylated on tyrosine 418 (Y418). Autophosphorylation of Src at Y418 in the catalytic domain is required for full catalytic activity of this kinase. Src is a non-receptor tyrosine kinase involved in signal transduction in numerous biological systems and is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Aberrant Src activity has been implicated in the development of numerous types of cancer. Due to the sequence homology surrounding Src Y418, this SC1T2M3 clone is predicted to cross-react with many Src family kinases including Src, Lck, Fyn, and Lyn.

Specificity of this SC1T2M3 clone was determined by ELISA, flow cytometry, and western blotting.