Phospho-SLP-76 (Y128) Mouse anti-Human, APC, Clone: HNDZ55, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-9037-42

100TEST Anti-Human phospho-SLP-76 (Y128) APC

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15558226

Quantity Price
1 £ 287.9 / 100 tests
Estimated Shipment date
from Supplier 23-01-2017
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Description and Specification

Specification

Antigen Phospho-SLP-76 (Y128)
Applications Flow Cytometry (Intracellular Staining)
Clone HNDZ55
Concentration 5μL (0.5μg)/test
Conjugate APC
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Lymphocyte cytosolic protein 2, LCP2
Host Species Mouse
Isotype IgG2b
Quantity 100 tests
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal

This HNDZ55 monoclonal antibody recognizes human SH2 domain-containing leukocyte protein of 76 kD (SLP-76) when phosphorylated on tyrosine 128 (Y128). SLP-76 is phosphorylated by ZAP-70 downstream of the T cell receptor (TCR). SLP-76 contains an acidic region that includes a PEST domain, several tyrosine residues that are phosphorylated following TCR ligation, a proline-rich domain, and an SH2 domain. Numerous proteins associate with SLP-76 including Vav1, GADS, and PLC gamma 1, supporting the notion that SLP-76 functions as a critical adaptor protein downstream of the TCR. SLP-76-deficient T cell lines or mice deficient in SLP-76 have shown that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

This antibody recognizes only human SLP-76 when phosphorylated on Y128. It is not recommended for staining of mouse cells.