missing translation for 'onlineSavingsMsg'
Learn More

Phospho-SLP-76 (Y128) Mouse anti-Human, APC, Clone: HNDZ55, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-9037-42

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15558226

  • £188.93 / 100 tests


Call for latest availability
+44 (0)1509 555 500
Add to basket

Disclaimers:

For Research Use Only.


Description

Description

This HNDZ55 monoclonal antibody recognizes human SH2 domain-containing leukocyte protein of 76 kD (SLP-76) when phosphorylated on tyrosine 128 (Y128). SLP-76 is phosphorylated by ZAP-70 downstream of the T cell receptor (TCR). SLP-76 contains an acidic region that includes a PEST domain, several tyrosine residues that are phosphorylated following TCR ligation, a proline-rich domain, and an SH2 domain. Numerous proteins associate with SLP-76 including Vav1, GADS, and PLC gamma 1, supporting the notion that SLP-76 functions as a critical adaptor protein downstream of the TCR. SLP-76-deficient T cell lines or mice deficient in SLP-76 have shown that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

This antibody recognizes only human SLP-76 when phosphorylated on Y128. It is not recommended for staining of mouse cells.
Specifications

Specifications

Phospho-SLP-76 (Y128)
HNDZ55
Allophycocyanin
Conjugated
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.5μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Lymphocyte cytosolic protein 2, LCP2
IgG2b
RUO
Primary
Human
Videos