Phospho-SLP-76 (Y128) Mouse anti-Human, APC, Clone: HNDZ55, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-9037-42

100TEST Anti-Human phospho-SLP-76 (Y128) APC

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15558226

Quantity Price
1 £ 188.93 / 100 tests
Estimated Shipment date
from Supplier 27-03-2017
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Description and Specification

Specification

Antigen Phospho-SLP-76 (Y128)
Format Conjugated
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias Lymphocyte cytosolic protein 2, LCP2
Host Species Mouse
Applications Flow Cytometry (Intracellular Staining)
Isotype IgG2b
Quantity 100 tests
Regulatory Status RUO
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Monoclonal or Polyclonal Monoclonal
Clone HNDZ55
Concentration 5μL (0.5μg)/test
Conjugate APC

This HNDZ55 monoclonal antibody recognizes human SH2 domain-containing leukocyte protein of 76 kD (SLP-76) when phosphorylated on tyrosine 128 (Y128). SLP-76 is phosphorylated by ZAP-70 downstream of the T cell receptor (TCR). SLP-76 contains an acidic region that includes a PEST domain, several tyrosine residues that are phosphorylated following TCR ligation, a proline-rich domain, and an SH2 domain. Numerous proteins associate with SLP-76 including Vav1, GADS, and PLC gamma 1, supporting the notion that SLP-76 functions as a critical adaptor protein downstream of the TCR. SLP-76-deficient T cell lines or mice deficient in SLP-76 have shown that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

This antibody recognizes only human SLP-76 when phosphorylated on Y128. It is not recommended for staining of mouse cells.