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Phospho-SLP-76 (Y128) Mouse anti-Human, APC, Clone: HNDZ55, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-9037-41

Code : NEW

Additional Details : Weight : 0.23750kg

 View more versions of this product

Product Code. 15548226

  • £78.88 / 25 tests


Estimated Shipment date
from Supplier 04-07-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This HNDZ55 monoclonal antibody recognizes human SH2 domain-containing leukocyte protein of 76 kD (SLP-76) when phosphorylated on tyrosine 128 (Y128). SLP-76 is phosphorylated by ZAP-70 downstream of the T cell receptor (TCR). SLP-76 contains an acidic region that includes a PEST domain, several tyrosine residues that are phosphorylated following TCR ligation, a proline-rich domain, and an SH2 domain. Numerous proteins associate with SLP-76 including Vav1, GADS, and PLC gamma 1, supporting the notion that SLP-76 functions as a critical adaptor protein downstream of the TCR. SLP-76-deficient T cell lines or mice deficient in SLP-76 have shown that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.

This antibody recognizes only human SLP-76 when phosphorylated on Y128. It is not recommended for staining of mouse cells.
Description & Specifications

Specifications

Phospho-SLP-76 (Y128)
HNDZ55
Allophycocyanin
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.5μg)/test
Conjugated
Lymphocyte cytosolic protein 2, LCP2
IgG2b
RUO
Primary
Human