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Phospho-mTOR (S2448) Mouse anti-Human, Mouse, eFluor 660, Clone: MRRBY, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 50-9718-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15580107

  • £80.62 / 25 tests


Estimated Shipment date
from Supplier 27-10-2017
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Disclaimers:

For Research Use Only.


Description

Description

This MRRBY monoclonal antibody recognizes human and mouse mammalian target of rapamycin (also known as mTOR, FRAP, RAFT) when phosphorylated on S2448. mTOR is a serine/threonine protein kinase that functions as an ATP and amino acid sensor as well as to balance nutrient availability with cell growth, proliferation, motility, survival, protein synthesis, and transcription. Activated mTOR increases production of enzymes necessary for glycolysis and controls the uptake of glucose and other nutrients. Increased glucose uptake and metabolism helps fulfill the energy needs for mTOR-driven cell growth and proliferation. When sufficient nutrients are available, mTOR transmits a positive signal to p70 S6 kinase and participates in the inactivation of the eIF4E inhibitor, 4E-BP1. mTOR is phosphorylated at S2448 via the PI3 kinase/Akt signaling pathway and is autophosphorylated at Ser2481. Due to its critical role in regulation of cell growth, survival, and metabolism, and because it is often abnormally regulated in tumors, mTOR is under investigation as a potential target for anti-cancer therapy.
Specifications

Specifications

Phospho-mTOR (S2448)
MRRBY
eFluor 660
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.5μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
mammalian target of rapamycin, FRAP, RAFT
IgG2a
RUO
Primary
Murine