Phospho-Mcl-1 (S159) Mouse anti-Human, Mouse, APC, Clone: RBCERNR, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-9038-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15578226

Quantity Price
1 £ 207.27 / 100 tests
Estimated Shipment date
from Supplier 03-05-2017
Add to basket


Description and Specification

Specification

Antigen Phospho-Mcl-1 (S159)
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG2b
Monoclonal or Polyclonal Monoclonal
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Primary or Secondary Primary
Gene Alias BCL2L3, EAT
Conjugate APC
Species Reactivity Human, Mouse
Host Species Mouse
Applications Flow Cytometry (Intracellular Staining)
Clone RBCERNR
Quantity 100 tests
Regulatory Status RUO
Concentration 5μL (0.25μg)/test
Format Conjugated

This RBCERNR monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1) when phosphorylated on serine 159 (S159). Mcl-1 is an anti-apoptotic protein that is a member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. PI3K activation of AKT results in the phosphorylation of GSK3 beta at serine 9 (S9) resulting in destabilization and degradation of GSK3 beta. Loss of GSK3 beta prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.