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Phospho-Mcl-1 (S159) Mouse anti-Human, Mouse, APC, Clone: RBCERNR, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-9038-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15568226

  • £84.99 / 25 tests


EU Stock 5
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Disclaimers:

For Research Use Only.


Description

Description

This RBCERNR monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1) when phosphorylated on serine 159 (S159). Mcl-1 is an anti-apoptotic protein that is a member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. PI3K activation of AKT results in the phosphorylation of GSK3 beta at serine 9 (S9) resulting in destabilization and degradation of GSK3 beta. Loss of GSK3 beta prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.
Specifications

Specifications

Phospho-Mcl-1 (S159)
RBCERNR
Allophycocyanin
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.25μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
BCL2L3, EAT
IgG2b
RUO
Primary
Murine
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