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Phospho-LCK (Y505) Mouse anti-Human, Mouse, PerCP-eFluor 710, Clone: SRRCHA, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 46-9076-42

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15559396

  • £219.50 / 100 tests


Estimated Shipment date
from Supplier 01-08-2017
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Disclaimers:

For Research Use Only.


Specifications

Description

This SRRCHA monoclonal antibody recognizes human and mouse LCK when phosphorylated on tyrosine 505 (Y505). Y505 is a negative-regulatory site that is phosphorylated by the kinase CSK. LCK is expressed in T cells where it associates with the cytoplasmic tails of the CD4 and CD8 co-receptors on T helper cells and cytotoxic T cells, respectively. When the TCR is engaged, LCK acts to phosphorylate the intracellular chains of CD3 and zeta chains of the TCR complex, allowing the cytoplasmic tyrosine kinase, ZAP-70, to bind to them. LCK then phosphorylates and activates ZAP-70, which then phosphorylates the adaptor protein, LAT, that serves as a docking site for a number of other proteins, including SLP-76, Grb2, and phospholipase C gamma1. Mice lacking expression of LCK show defects in T cell development and function.
Description & Specifications

Specifications

Phospho-LCK (Y505)
SRRCHA
PerCP-eFluor 710
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Murine
100 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material. This tandem dye is sensitive to photo-induced oxidation. Protect this vial from light during storage
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.06μg)/test
Conjugated
lymphocyte-specific protein tyrosine kinase, Leukocyte C-terminal Src kinase, p56lck
IgG1
RUO
Primary
Murine