Phospho-I kappa B alpha (IKB-a) (S32/S36) Mouse anti-Human, Mouse, eFluor 660, Clone: RILYB3R, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-9035-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15550067

Quantity Price
1 £ 78.88 / 25 tests
EU Stock 2
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone RILYB3R
Conjugate eFluor 660
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Gene Alias Inhibitor of kappa B alpha
Isotype IgG2b
Regulatory Status RUO
Host Species Mouse
Quantity 25 tests
Species Reactivity Human, Mouse
Antigen Phospho-I kappa B alpha (IKB-a) (S32/S36)
Applications Flow Cytometry (Intracellular Staining)
Concentration 5μL (0.125μg)/test
Format Conjugated

This RILYB3R monoclonal antibody recognizes human and mouse nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (I kappa B alpha) when phosphorylated on serines 32 and 36 (S32/S36). I kappa B alpha is one member of a family of cellular proteins that functions to inhibit classical/canonical NF-kappa B signaling by masking the nuclear localization signals (NLS) of NF-kappa B proteins and keeping them sequestered in an inactive state in the cytoplasm. Classical/canonical NF-kappa B signaling is initiated in response to myriad stimuli including engagement of T cell and B cell receptors, growth factors, and inflammatory stimuli (reactive oxygen species, TNF alpha, IL-1) and results in the activation of the I kappa B kinase (IKK) complex that includes IKK alpha, IKK beta, and NEMO. IKK phosphorylates I kappa B alpha resulting in its ubiquitination, degradation, and subsequent translocation of NF-kappa B transcription factor proteins into the nucleus.