Phospho-Histone H3 (S28) Rat anti-Human, Mouse, eFluor 660, Clone: HTA28, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-9124-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15500087

Quantity Price
1 £ 72.77 / 25 tests
Estimated Shipment date
from Supplier 05-04-2017
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Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Concentration 5μL (0.25μg)/test
Primary or Secondary Primary
Species Reactivity Human, Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Applications Flow Cytometry (Intracellular Staining)
Clone HTA28
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate eFluor 660
Host Species Rat
Isotype IgG2a
Antigen Phospho-Histone H3 (S28)
Regulatory Status RUO
Quantity 25 tests
Format Conjugated

The HTA28 monoclonal antibody recognizes phosphorylated serine 28 of human, mouse, rat, bovine, and hamster histone H3. This 15kDa protein is a component of eukaryotic chromatin that is involved in forming the nucleosome structure. Histone H3 can be phosphorylated at serine 10 and serine 28. Studies have demonstrated that phosphorylation at serine 28 is mediated by MSK1 following activation by the MAP kinase signaling pathway in response to tumor promoters (e.g., UV and EGF) and oncoproteins (e.g., c-Myc, c-Jun, and c-Fos). Histone H3 serine 28 phosphorylation has been linked to chromosome condensation during mitosis, cell transformation, and regulation of RNA polymerase III transcription machinery.