Phospho-Histone H3 (S28) Rat anti-Human, Mouse, eFluor 660, Clone: HTA28, eBioscience™

Rat Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-9124-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15510087

Quantity Price
1 £ 188.93 / 100 tests
Estimated Shipment date
from Supplier 04-04-2017
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Description and Specification

Specification

Isotype IgG2a
Quantity 100 tests
Host Species Rat
Monoclonal or Polyclonal Monoclonal
Concentration 5μL (0.25μg)/test
Conjugate eFluor 660
Antigen Phospho-Histone H3 (S28)
Primary or Secondary Primary
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Species Reactivity Human, Mouse
Format Conjugated
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone HTA28

The HTA28 monoclonal antibody recognizes phosphorylated serine 28 of human, mouse, rat, bovine, and hamster histone H3. This 15kDa protein is a component of eukaryotic chromatin that is involved in forming the nucleosome structure. Histone H3 can be phosphorylated at serine 10 and serine 28. Studies have demonstrated that phosphorylation at serine 28 is mediated by MSK1 following activation by the MAP kinase signaling pathway in response to tumor promoters (e.g., UV and EGF) and oncoproteins (e.g., c-Myc, c-Jun, and c-Fos). Histone H3 serine 28 phosphorylation has been linked to chromosome condensation during mitosis, cell transformation, and regulation of RNA polymerase III transcription machinery.