Phospho-ERK1/2 (T202/Y204) Mouse anti-Human, Mouse, APC, Clone: MILAN8R, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 17-9109-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15548236

Quantity Price
1 £ 74.51 / 25 tests
EU Stock 4
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Description and Specification

Specification

Gene Alias MAPK, ERK, p42/p44
Monoclonal or Polyclonal Monoclonal
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Clone MILAN8R
Isotype IgG1
Antigen Phospho-ERK1/2 (T202/Y204)
Applications Flow Cytometry (Intracellular Staining)
Primary or Secondary Primary
Species Reactivity Human, Mouse
Host Species Mouse
Quantity 25 tests
Format Conjugated
Conjugate APC
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Concentration 5μL (0.03μg)/test

This MILAN8R monoclonal antibody recognizes human and mouse extracellular signal-regulated kinases 1 and 2 (also known as ERK1/2, p44/p42, or MAPK3/1) when phosphorylated on T202/Y204. ERK1/2 belong to a family of conserved serine/threonine protein kinases known as mitogen-activated protein kinases (MAPKs) that are involved in many cellular programs such as proliferation, differentiation, motility, and survival. ERK1/2 signaling is activated in response to numerous extracellular stimuli including mitogens, growth factors, and cytokines. The primary activators of ERK1/2 are MEK1 and MEK2 which act by phosphorylating the activation loop residues T202/Y204 and T185/Y187 in ERK1 and ERK2, respectively. Several downstream targets of ERK1/2 have been identified, including p90RSK and the transcription factor Elk-1. ERK1/2 are negatively regulated by MAPK phosphatases, known as DUSPs or MKPs, as well as by chemical inhibitors of MEK including U0126 and PD98059. Disruption of the ERK pathway is common in many types of cancer.

Specificity of this MILAN8R clone was determined by ELISA, flow cytometry, and western blotting.