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phospho Chk2 Mouse anti-Human, Mouse, PE, Clone: ebchk2, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 12-9508-41

Code : NEW

Additional Details : Weight : 0.23750kg

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Product Code. 15527216

  • POA / 25 tests


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Disclaimers:

For Research Use Only.


Description

Description

This ebchk2 monoclonal antibody recognizes human and mouse Checkpoint Kinase 2 (Chk2) when phosphorylated on threonine 68 (T68). Chk2 is a cell cycle checkpoint regulator and tumor suppressor. Along with Chk1, it plays a critical role in the cellular response to DNA damage, and is particularly important during G2/M transition. Chk2 is activated via phosphorylation on T68 by the kinase ATM, which responds primarily to double-stranded DNA breaks. Upon activation, Chk2 functions include inhibition of Cdc25 family phosphatases and activation of p53, both of which prevent progression of the cell cycle. Abnormal regulation of the ATM-Chk2 pathway is often observed in cancer.
Specifications

Specifications

phospho Chk2
ebchk2
PE
Conjugated
Murine
25 Tests
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Flow Cytometry (Intracellular Staining)
5μL (0.125μg)/test
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Checkpoint kinase 2
IgG2b
RUO
Primary
Murine