phospho Chk2 Mouse anti-Human, Mouse, PE, Clone: ebchk2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-9508-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15537216

Quantity Price
1 £ 201.16 / 100 tests
EU Stock 2
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Antigen phospho Chk2
Conjugate PE
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Isotype IgG2b
Gene Alias Checkpoint kinase 2
Primary or Secondary Primary
Applications Flow Cytometry (Intracellular Staining)
Quantity 100 tests
Clone ebchk2
Monoclonal or Polyclonal Monoclonal
Species Reactivity Human, Mouse
Host Species Mouse
Concentration 5μL (0.125μg)/test
Regulatory Status RUO
Format Conjugated

This ebchk2 monoclonal antibody recognizes human and mouse Checkpoint Kinase 2 (Chk2) when phosphorylated on threonine 68 (T68). Chk2 is a cell cycle checkpoint regulator and tumor suppressor. Along with Chk1, it plays a critical role in the cellular response to DNA damage, and is particularly important during G2/M transition. Chk2 is activated via phosphorylation on T68 by the kinase ATM, which responds primarily to double-stranded DNA breaks. Upon activation, Chk2 functions include inhibition of Cdc25 family phosphatases and activation of p53, both of which prevent progression of the cell cycle. Abnormal regulation of the ATM-Chk2 pathway is often observed in cancer.