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Phospho-BTK/ITK (Tyr551, Tyr511) Monoclonal Antibody (M4G3LN), PE, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

£275.00

Specifications

Antigen Phospho-BTK/ITK (Tyr551, Tyr511)
Clone M4G3LN
Concentration 5 μL/Test
Applications Flow Cytometry
Classification Monoclonal
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Products 1
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15567156
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Affymetrix eBioscience
12-9015-42
100 Tests
£275.00
100 tests
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Estimated Shipment: 08-05-2024
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Description

Description

Description: This M4G3LN monoclonal antibody recognizes human and mouse Bruton's tyrosine kinase (also known as BTK, agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase)/interleukin-2-inducible tyrosine kinase (also known as ITK, T-cell-specific kinase, Tyrosine-protein kinase Lyk) when phosphorylated on Y551 and Y511, respectively. In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family. The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180. Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively. People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency. Specificity of this M4G3LN clone was determined by ELISA, flow cytometry, and western blotting. Applications Reported: This M4G3LN antibody has been reported for use in intracellular staining followed by flow cytometric analysis.

In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family. The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180. Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively. People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency.
Specifications

Specifications

Phospho-BTK/ITK (Tyr551, Tyr511)
5 μL/Test
Monoclonal
Liquid
RUO
12229, 16428, 3702, 695
IgG2b κ
Affinity chromatography
Antibody
M4G3LN
Flow Cytometry
PE
Mouse
Human, Mouse
BTK, ITK
Primary
4° C, store in dark, DO NOT FREEZE!
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