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Phospho-BTK/ITK (Tyr551, Tyr511) Monoclonal Antibody (M4G3LN), PE, eBioscience™, Invitrogen™
Mouse Monoclonal Antibody
£275.00
Specifications
Antigen | Phospho-BTK/ITK (Tyr551, Tyr511) |
---|---|
Clone | M4G3LN |
Concentration | 5 μL/Test |
Applications | Flow Cytometry |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15567156
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Affymetrix eBioscience
12-9015-42 |
100 Tests |
£275.00
100 tests |
Estimated Shipment: 25-04-2024 Log in to see stock. |
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Description
Description: This M4G3LN monoclonal antibody recognizes human and mouse Bruton′s tyrosine kinase (also known as BTK, agammaglobulinaemia tyrosine kinase, B-cell progenitor kinase)/interleukin-2-inducible tyrosine kinase (also known as ITK, T-cell-specific kinase, Tyrosine-protein kinase Lyk) when phosphorylated on Y551 and Y511, respectively. In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family. The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180. Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively. People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency. Specificity of this M4G3LN clone was determined by ELISA, flow cytometry, and western blotting. Applications Reported: This M4G3LN antibody has been reported for use in intracellular staining followed by flow cytometric analysis.
In addition to Src family and SYK family kinases, B cells and T cells express a third family of receptor-proximal kinases called the Tec kinase family. The B cell-specific Tec family kinase is BTK; T cells express ITK as well as Tec and Rlk. Tec family kinases play an indispensable role in activation of phospholipase C and activation of calcium-dependent signaling cascades following antigen receptor triggering. BTK has been implicated in propagating signals downstream of LPS-TLR4 in B cells via signaling through the TLR4 co-receptor RP105/CD180. Mice congenitally lacking BTK or ITK show profound defects in B cell or T cell development and signaling, respectively. People with mutations or deletions in BTK suffer from X-linked agammaglobulinemia and X-linked immunodeficiency.Specifications
Phospho-BTK/ITK (Tyr551, Tyr511) | |
5 μL/Test | |
Monoclonal | |
Liquid | |
RUO | |
12229, 16428, 3702, 695 | |
IgG2b κ | |
Affinity chromatography | |
Antibody |
M4G3LN | |
Flow Cytometry | |
PE | |
Mouse | |
Human, Mouse | |
BTK, ITK | |
Primary | |
4° C, store in dark, DO NOT FREEZE! |
For Research Use Only.