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PF 915275, Tocris Bioscience™

Potent and selective 11β-hydroxysteroid dehydrogenase inhibitor

Brand:  Tocris (Bio-Techne) 329150

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13462724

  • £552.52 / 50mg


Estimated Shipment
31-10-2018
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Description

Description

Potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor (Ki = 2.3 nM) that displays little activity at 11βHSD2 (1.5% inhibition at 10μM). Inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro (EC50 = 15 nM) and has antidiabetic activity in vivo. Orally active.
Specifications

Chemical Identifiers

857290-04-1
350.396
n-6-aminopyridin-2-yl-4'-cyanobiphenyl-4-sulfonamide, n-6-aminopyridin-2-yl-4'-cyano-1,1'-biphenyl-4-sulfonamide, d07fhw, n-pyridin-2-yl arylsulfonamide, 26, n-6-aminopyridin-2-yl 4'-cyanobiphenyl-4-sulfonamide, n-6-amino-2-pyridinyl-4'-cyano-1,1'-biphenyl-4-sulfonamide, 1,1'-biphenyl-4-sulfonamide, n-6-amino-2-pyridinyl-4'-cyano, n-6-amino-pyridin-2-yl-4'-cyano-1,1'-biphenyl-4-sulfonamide
N-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide
C18H14N4O2S
ZESFDAKNYJQYKO-UHFFFAOYSA-N
23725123
C1=CC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N

Specifications

PF 915275
857290-04-1
n-6-aminopyridin-2-yl-4'-cyanobiphenyl-4-sulfonamide, n-6-aminopyridin-2-yl-4'-cyano-1,1'-biphenyl-4-sulfonamide, d07fhw, n-pyridin-2-yl arylsulfonamide, 26, n-6-aminopyridin-2-yl 4'-cyanobiphenyl-4-sulfonamide, n-6-amino-2-pyridinyl-4'-cyano-1,1'-biphenyl-4-sulfonamide, 1,1'-biphenyl-4-sulfonamide, n-6-amino-2-pyridinyl-4'-cyano, n-6-amino-pyridin-2-yl-4'-cyano-1,1'-biphenyl-4-sulfonamide
C1=CC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)C#N)N
350.396
350.39
50mg
C18H14N4O2S
ZESFDAKNYJQYKO-UHFFFAOYSA-N
N-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide
23725123
>98%
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