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PF 670462, Tocris Bioscience™

Potent and selective CK1ε and CK1δ inhibitor

Brand:  Tocris (Bio-Techne) 331650

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13432774

  • £853.96 / 50mg

Estimated Shipment
14-09-2020

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Description

Description

Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.
Specifications

Chemical Identifiers

950912-80-8
410.318
unii-d68ans5i8b, d68ans5i8b, 4-1-cyclohexyl-4-4-fluorophenyl-1h-imidazol-5-yl-2-pyrimidinaminedihydrochloride, 4-1-cyclohexyl-4-4-fluorophenyl-1h-imidazol-5-yl-2-pyrimidinamine dihydrochloride, 4-1-cyclohexyl-4-4-fluorophenyl-1h-imidazol-5-yl pyrimidin-2-amine dihydrochloride, 4-3-cyclohexyl-5-4-fluorophenyl imidazol-4-yl pyrimidin-2-amine;dihydrochloride, c19h20fn5.2clh, 2-pyrimidinamine, 4-1-cyclohexyl-4-4-fluorophenyl-1h-imidazol-5-yl-, hydrochloride 1:2, 4-3-cyclohexyl-5-4-fluorophenyl imidazol-4-yl pyrimidin-2-amine dihydrochloride
CHEBI:87236
C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl
C19H22Cl2FN5
PSNKGVAXBSAHCH-UHFFFAOYSA-N
51049607
4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine;dihydrochloride

Specifications

PF 670462
950912-80-8
unii-d68ans5i8b, d68ans5i8b, 4-1-cyclohexyl-4-4-fluorophenyl-1h-imidazol-5-yl-2-pyrimidinaminedihydrochloride, 4-1-cyclohexyl-4-4-fluorophenyl-1h-imidazol-5-yl-2-pyrimidinamine dihydrochloride, 4-1-cyclohexyl-4-4-fluorophenyl-1h-imidazol-5-yl pyrimidin-2-amine dihydrochloride, 4-3-cyclohexyl-5-4-fluorophenyl imidazol-4-yl pyrimidin-2-amine;dihydrochloride, c19h20fn5.2clh, 2-pyrimidinamine, 4-1-cyclohexyl-4-4-fluorophenyl-1h-imidazol-5-yl-, hydrochloride 1:2, 4-3-cyclohexyl-5-4-fluorophenyl imidazol-4-yl pyrimidin-2-amine dihydrochloride
C1CCC(CC1)N2C=NC(=C2C3=NC(=NC=C3)N)C4=CC=C(C=C4)F.Cl.Cl
410.318
CHEBI:87236
>99%
50mg
C19H22Cl2FN5
PSNKGVAXBSAHCH-UHFFFAOYSA-N
4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine;dihydrochloride
51049607
410.32
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