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PF 477736, Tocris Bioscience™

Selective Chk1 inhibitor

Brand:  Tocris (Bio-Techne) 427710

Code : Z1

Additional Details : Weight : 0.00001kg

Quantity 10mg

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Product Code. 13464474

  • £223.09 / 10mg


Estimated Shipment
03-09-2018
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Description

Description

Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Enhances docetaxel (Cat. No. 4056) efficacy in tumor cells and xenografts.
Specifications

Chemical Identifiers

952021-60-2
419.489
(R)-α-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide
C22H25N7O2
YFNWWNRZJGMDBR-LJQANCHMSA-N
16750408

Specifications

PF 477736
>99%
C22H25N7O2
YFNWWNRZJGMDBR-LJQANCHMSA-N
419.489
419.48
952021-60-2
10mg
(R)-α-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]-cyclohexaneacetamide
CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)C(C5CCCCC5)N
16750408
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