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PF 477736, Tocris Bioscience™

Selective Chk1 inhibitor

Brand:  Tocris (Bio-Techne) 427710

Code : Z1

Additional Details : Weight : 0.00001kg

Quantity 10mg

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Product Code. 13464474

  • £223.09 / 10mg


Estimated Shipment
08-01-2019
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Description

Description

Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Enhances docetaxel (Cat. No. 4056) efficacy in tumor cells and xenografts.
Specifications

Chemical Identifiers

952021-60-2
419.489
unii-xo23pgz0sm, 2~ r-2-azanyl-2-cyclohexyl-~ n-2-1-methylpyrazol-4-yl-9-oxidanylidene-3,10,11-triazatricyclo 6.4.1.0^ 4,13 trideca-1,4,6,8 13 ,11-pentaen-6-yl ethanamide, xo23pgz0sm, 2r-2-amino-2-cyclohexyl-n-2-1-methyl-1h-pyrazol-4-yl-6-oxo-5,6-dihydro-1h-1,2 diazepino 4,5,6-cd indol-8-yl-acetamide, r-2-amino-2-cyclohexyl-n-2-1-methyl-1h-pyrazol-4-yl-6-oxo-5,6-dihydro-1h-1,2 diazepino 4,5,6-cd indol-8-yl acetamide, 2r-2-amino-2-cyclohexyl-n-2-1-methylpyrazol-4-yl-9-oxo-3,10,11-triazatricyclo 6.4.1.0?, 1 3 trideca-1,4,6,8 13 ,11-pentaen-6-yl acetamide, d0u9iq, cyclohexaneacetamide, alpha-amino-n-5,6-dihydro-2-1-methyl-1h-pyrazol-4-yl-6-oxo-1h-pyrrolo 4,3,2-ef 2,3 benzodiazepin-8-yl-, alphar, pf hplc, ar-, a-amino-n-5,6-dihydro-2-1-methyl-1h-pyrazol-4-yl-6-oxo-1h-pyrrolo 4,3,2-ef 2,3 benzodiazepin-8-yl cyclohexaneacetamide
CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)C(C5CCCCC5)N
C22H25N7O2
YFNWWNRZJGMDBR-LJQANCHMSA-N
16750408

Specifications

PF 477736
952021-60-2
unii-xo23pgz0sm, 2~ r-2-azanyl-2-cyclohexyl-~ n-2-1-methylpyrazol-4-yl-9-oxidanylidene-3,10,11-triazatricyclo 6.4.1.0^ 4,13 trideca-1,4,6,8 13 ,11-pentaen-6-yl ethanamide, xo23pgz0sm, 2r-2-amino-2-cyclohexyl-n-2-1-methyl-1h-pyrazol-4-yl-6-oxo-5,6-dihydro-1h-1,2 diazepino 4,5,6-cd indol-8-yl-acetamide, r-2-amino-2-cyclohexyl-n-2-1-methyl-1h-pyrazol-4-yl-6-oxo-5,6-dihydro-1h-1,2 diazepino 4,5,6-cd indol-8-yl acetamide, 2r-2-amino-2-cyclohexyl-n-2-1-methylpyrazol-4-yl-9-oxo-3,10,11-triazatricyclo 6.4.1.0?, 1 3 trideca-1,4,6,8 13 ,11-pentaen-6-yl acetamide, d0u9iq, cyclohexaneacetamide, alpha-amino-n-5,6-dihydro-2-1-methyl-1h-pyrazol-4-yl-6-oxo-1h-pyrrolo 4,3,2-ef 2,3 benzodiazepin-8-yl-, alphar, pf hplc, ar-, a-amino-n-5,6-dihydro-2-1-methyl-1h-pyrazol-4-yl-6-oxo-1h-pyrrolo 4,3,2-ef 2,3 benzodiazepin-8-yl cyclohexaneacetamide
CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)C(C5CCCCC5)N
16750408
>99%
10mg
C22H25N7O2
YFNWWNRZJGMDBR-LJQANCHMSA-N
419.489
419.48
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