Tocris Bioscience™ Pexidartinib

Product Code. 18717136

Brand: Tocris Bioscience™ 7590/10

Description

Potent CSF-1R inhibitor

Pexidartinib is a potent colony-stimulating factor-1 receptor (CSF-1R) tyrosine kinase inhibitor (IC50 = 20 nM). In the B16F10 mouse melanoma model, Pexidartinib reduces the systemic and local accumulation of macrophages without affecting Gr-1+ myeloid derived suppressor cells. When combined with tumor-specific CD8 T cell immunotherapy, Pexidartinib promotes the control of tumor growth. In the BRAFV600E-driven mouse melanoma model, Pexidartinib improves the efficacy of adoptive cell therapy with reduction of TIMs and an increase in tumor-infiltrating lymphocytes and T cells. Orally bioavailable.

Specifications

• Chemical Name or Material: N-[5-[(5-Chloro-1 H-pyrrolo[2,3-b]pyridin-3-yl)methyl]-2-pyridinyl]-6-(trifluoromethyl)-3-pyridinemethanamine
• CAS: 1029044-16-3
• Quantity: 10 mg
• Target: Additional RTK Inhibitors
• Molecular Formula: C₂₀H₁₅ClF₃N₅
• Purity: 98%