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Tocris™ PD 98059

MEK inhibitor

Brand:  Tocris™ 12131

Code : Z1

Additional Details : Weight : 0.01000kg

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Product Code. 13488893

  • £73.40 / 1mg


Estimated Shipment
05-01-2018
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Disclaimers:

For Research Use Only


Description

Description

Inhibitor of mitogen-activated protein kinase kinase (MKK/ MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™ .
Specifications

Specifications

PD 98059
>98
1mg
PD 98059
267.28
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