PD 407824, Tocris Bioscience™

Selective inhibitor of Chk1 and Wee1

Brand:  Tocris (Bio-Techne) 269410

Product Code. 13461744

Description

Selective inhibitor of checkpoint kinases Chk1 and Wee1 (IC50 values are 47 and 97 nM respectively). Displays selectivity over a range of other protein kinases; IC50 values are 3.4, 3.75, > 5, > 50, > 50 and > 50 μM for PKC, CDK4, other CDKs, c-Src, PDGFR and FGFR respectively.

Chemical Identifiers

• CAS: 622864-54-4
• Molecular Weight (g/mol): 328.327
• Synonym: 9-hydroxy-4-phenyl-6h-pyrrolo 3,4-c carbazole-1,3-dione, 9-hydroxy-4-phenylpyrrolo 3,4-c carbazole-1,3 2h,6h-dione, 9-hydroxy-4-phenyl-2h,6h-pyrrolo 3,4-c carbazole-1,3-dione, pd hplc, 9-hydroxy-4-phenyl-pyrrolo 3,4-c carbazole-1,3 2h,6h-dione, pyrrolo 3,4-c carbazole-1,3 2h,6h-dione, 9-hydroxy-4-phenyl, 14-hydroxy-7-phenyl-4,10-diazatetracyclo 7.7.0.0^ 2,6 .0^ 11,16 hexadeca-1,6,8,11,13,15-hexaene-3,5-dione
• IUPAC Name: 9-hydroxy-4-phenyl-6H-pyrrolo[3,4-c]carbazole-1,3-dione

• Molecular Formula: C20H12N2O3
• InChI Key: IAUZTOZLTFSMIE-UHFFFAOYSA-N
• PubChem CID: 4369491
• SMILES: C1=CC=C(C=C1)C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O

Specifications

• Quantity: 10mg
• CAS: 622864-54-4
• Synonym: 9-hydroxy-4-phenyl-6h-pyrrolo 3,4-c carbazole-1,3-dione, 9-hydroxy-4-phenylpyrrolo 3,4-c carbazole-1,3 2h,6h-dione, 9-hydroxy-4-phenyl-2h,6h-pyrrolo 3,4-c carbazole-1,3-dione, pd hplc, 9-hydroxy-4-phenyl-pyrrolo 3,4-c carbazole-1,3 2h,6h-dione, pyrrolo 3,4-c carbazole-1,3 2h,6h-dione, 9-hydroxy-4-phenyl, 14-hydroxy-7-phenyl-4,10-diazatetracyclo 7.7.0.0^ 2,6 .0^ 11,16 hexadeca-1,6,8,11,13,15-hexaene-3,5-dione
• SMILES: C1=CC=C(C=C1)C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O
• Molecular Weight (g/mol): 328.327
• Formula Weight: 328.32

• Chemical Name or Material: PD 407824
• Molecular Formula: C20H12N2O3
• InChI Key: IAUZTOZLTFSMIE-UHFFFAOYSA-N
• IUPAC Name: 9-hydroxy-4-phenyl-6H-pyrrolo[3,4-c]carbazole-1,3-dione
• PubChem CID: 4369491
• Percent Purity: >98%