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PD 173074, Tocris Bioscience™

FGFR1 and -3 inhibitor

Brand:  Tocris (Bio-Techne) 304450

Code : Z1

Additional Details : Weight : 0.01000kg

Quantity 50mg

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Product Code. 13432294

  • £851.13 / 50mg

Estimated Shipment date
from Supplier 30-03-2020

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Description

Description

Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ∽100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.
Specifications

Chemical Identifiers

219580-11-7
523.682
1-tert-butyl-3-2-4-diethylamino butyl amino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, unii-a4tll8634y, 3-tert-butyl-1-2-4-diethylamino butyl amino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, fgf/vegf receptor tyrosine kinase inhibitor, pd173074, 1-tert-butyl-3-2-4-diethylamino butylamino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, 2fgi, 1-t-butyl-3-6-3,5-dimethoxyphenyl-2-4-diethylaminobutylamino-pyrido 2,3-d pyrimidin-7-yl urea, 1-tert-butyl-3-6-3,5-dimethoxy-phenyl-2-4-diethylamino-butylamino-pyrido 2,3-d pyrimidin-7-yl-urea
CHEBI:63448
CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
C28H41N7O3
DXCUKNQANPLTEJ-UHFFFAOYSA-N
1401
1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea

Specifications

PD 173074
219580-11-7
1-tert-butyl-3-2-4-diethylamino butyl amino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, unii-a4tll8634y, 3-tert-butyl-1-2-4-diethylamino butyl amino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, fgf/vegf receptor tyrosine kinase inhibitor, pd173074, 1-tert-butyl-3-2-4-diethylamino butylamino-6-3,5-dimethoxyphenyl pyrido 2,3-d pyrimidin-7-yl urea, 2fgi, 1-t-butyl-3-6-3,5-dimethoxyphenyl-2-4-diethylaminobutylamino-pyrido 2,3-d pyrimidin-7-yl urea, 1-tert-butyl-3-6-3,5-dimethoxy-phenyl-2-4-diethylamino-butylamino-pyrido 2,3-d pyrimidin-7-yl-urea
CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C
523.682
CHEBI:63448
>98%
50mg
C28H41N7O3
DXCUKNQANPLTEJ-UHFFFAOYSA-N
1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
1401
523.67
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