PARP1 Mouse anti-Human, Clone: HLNC4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 14-6668-80

UNSPSC: 12352200

Code: Z2

Additional Details:
Additional Details: Weight: 0.01000kg



Disclaimers: For Research Use Only.

Product Code. 15287927

Quantity Price
1 £ 91.11 / 25µg
Estimated Shipment date
from Supplier 08-05-2017
Add to basket


Description and Specification

Specification

Monoclonal or Polyclonal Monoclonal
Gene Alias poly ADP-ribose polymerase
Primary or Secondary Primary
Storage Requirements Store at 2-8°C.
Concentration 0.5mg/mL
Quantity 25μg
Species Reactivity Human
Conjugate Unlabeled
Host Species Mouse
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Antigen PARP1
Regulatory Status RUO
Format Purified
Isotype IgG1
Clone HLNC4
Applications Western Blotting

This HLNC4 monoclonal antibody reacts with human poly (ADP-ribose) polymerase (PARP1). This ubiquitous 116kDa nuclear enzyme is involved in DNA repair. During apoptosis, active caspases -3, -6 and -7 cleave PARP1 after Asp214, thereby inactivating PARP1 and generating two apoptotic fragments sized 85kDa and 25 kDa.

The HLNC4 antibody specifically recognizes the 85kDa PARP1 fragment produced after cleavage and does not recognize the full-length 116kDa protein.The following peptide was used as the immunogen: NH2-GVDEVAKKKSKKEKDC-COOH.