PARP1 (Cleaved) Mouse anti-Human, PE, Clone: HLNC4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-6668-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15537076

Quantity Price
1 £ 170.59 / 100 tests
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Gene Alias poly ADP-ribose polymerase
Formulation aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary
Host Species Mouse
Species Reactivity Human
Antigen PARP1 (Cleaved)
Primary or Secondary Primary
Isotype IgG2b
Clone HLNC4
Regulatory Status RUO
Concentration 5μL (0.004μg)/test
Format Conjugated
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal
Applications Flow Cytometry (Intracellular Staining)
Conjugate PE
Quantity 100 tests

This HLNC4 monoclonal antibody reacts with human poly (ADP-ribose) polymerase (PARP1). This ubiquitous 116kDa nuclear enzyme is involved in DNA repair. During apoptosis, active caspases -3, -6 and -7 cleave PARP1 after Asp214, thereby inactivating PARP1 and generating two apoptotic fragments sized 85kDa and 25 kDa.

The HLNC4 antibody specifically recognizes the 85kDa PARP1 fragment produced after cleavage and does not recognize the full-length 116kDa protein.The following peptide was used as the immunogen: NH2-GVDEVAKKKSKKEKDC-COOH.