PARP1 (Cleaved) Mouse anti-Human, PE, Clone: HLNC4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-6668-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15527076

Quantity Price
1 £ 103.33 / 25 tests
Estimated Shipment date
from Supplier 03-04-2017
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Description and Specification

Specification

Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Format Conjugated
Applications Flow Cytometry (Intracellular Staining)
Regulatory Status RUO
Isotype IgG2b
Concentration 5μL (0.004μg)/test
Formulation aqueous buffer, 0.09% sodium azide, contains stabilizer if necessary
Host Species Mouse
Species Reactivity Human
Conjugate PE
Antigen PARP1 (Cleaved)
Quantity 25 tests
Gene Alias poly ADP-ribose polymerase
Clone HLNC4

This HLNC4 monoclonal antibody reacts with human poly (ADP-ribose) polymerase (PARP1). This ubiquitous 116kDa nuclear enzyme is involved in DNA repair. During apoptosis, active caspases -3, -6 and -7 cleave PARP1 after Asp214, thereby inactivating PARP1 and generating two apoptotic fragments sized 85kDa and 25 kDa.

The HLNC4 antibody specifically recognizes the 85kDa PARP1 fragment produced after cleavage and does not recognize the full-length 116kDa protein.The following peptide was used as the immunogen: NH2-GVDEVAKKKSKKEKDC-COOH.