PARP Mouse anti-Human, eFluor 450, Clone: HLNC4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-6668-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15599786

Quantity Price
1 £ 84.99 / 25 tests
Estimated Shipment date
from Supplier 05-05-2017
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Clone HLNC4
Host Species Mouse
Primary or Secondary Primary
Isotype IgG1
Applications Flow Cytometry (Intracellular Staining)
Gene Alias poly ADP-ribose polymerase
Quantity 25 tests
Concentration 5μL (0.06μg)/test
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal or Polyclonal Monoclonal
Antigen PARP
Regulatory Status RUO
Format Conjugated
Conjugate eFluor 450

This HLNC4 monoclonal antibody reacts with human poly (ADP-ribose) polymerase (PARP1). This ubiquitous 116kDa nuclear enzyme is involved in DNA repair. During apoptosis, active caspases -3, -6 and -7 cleave PARP1 after Asp214, thereby inactivating PARP1 and generating two apoptotic fragments sized 85kDa and 25 kDa.

The HLNC4 antibody specifically recognizes the 85kDa PARP1 fragment produced after cleavage and does not recognize the full-length 116kDa protein.The following peptide was used as the immunogen: NH2-GVDEVAKKKSKKEKDC-COOH.