PARP Mouse anti-Human, eFluor 450, Clone: HLNC4, eBioscience™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 48-6668-42

Product Code. 15509796

Disclaimers:

For Research Use Only.

Description

This HLNC4 monoclonal antibody reacts with human poly (ADP-ribose) polymerase (PARP1). This ubiquitous 116kDa nuclear enzyme is involved in DNA repair. During apoptosis, active caspases -3, -6 and -7 cleave PARP1 after Asp214, thereby inactivating PARP1 and generating two apoptotic fragments sized 85kDa and 25 kDa.

The HLNC4 antibody specifically recognizes the 85kDa PARP1 fragment produced after cleavage and does not recognize the full-length 116kDa protein.The following peptide was used as the immunogen: NH2-GVDEVAKKKSKKEKDC-COOH.

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Specifications

• Antigen: PARP
• Clone: HLNC4
• Conjugate: eFluor 450
• Format: Conjugated
• Host Species: Murine
• Quantity: 100 Tests
• Storage Requirements: Store at 2-8°C. Do not freeze. Light-sensitive material.
• Monoclonal or Polyclonal: Monoclonal

• Applications: Flow Cytometry (Intracellular Staining)
• Concentration: 5μL (0.06μg)/test
• Formulation: aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Gene Alias: poly ADP-ribose polymerase
• Isotype: IgG1
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human