PARP Mouse anti-Human, eFluor 450, Clone: HLNC4, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 48-6668-42

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15509796

Quantity Price
1 £ 188.93 / 100 tests
EU Stock 1
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Description and Specification

Specification

Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Regulatory Status RUO
Isotype IgG1
Antigen PARP
Applications Flow Cytometry (Intracellular Staining)
Primary or Secondary Primary
Format Conjugated
Quantity 100 tests
Conjugate eFluor 450
Clone HLNC4
Concentration 5μL (0.06μg)/test
Gene Alias poly ADP-ribose polymerase
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Host Species Mouse
Species Reactivity Human
Monoclonal or Polyclonal Monoclonal

This HLNC4 monoclonal antibody reacts with human poly (ADP-ribose) polymerase (PARP1). This ubiquitous 116kDa nuclear enzyme is involved in DNA repair. During apoptosis, active caspases -3, -6 and -7 cleave PARP1 after Asp214, thereby inactivating PARP1 and generating two apoptotic fragments sized 85kDa and 25 kDa.

The HLNC4 antibody specifically recognizes the 85kDa PARP1 fragment produced after cleavage and does not recognize the full-length 116kDa protein.The following peptide was used as the immunogen: NH2-GVDEVAKKKSKKEKDC-COOH.