Osteopontin Mouse anti-Human, eFluor 660, Clone: 2F10, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 50-9096-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15510077

Quantity Price
1 £ 78.88 / 25 tests
Estimated Shipment date
from Supplier 02-05-2017
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Description and Specification

Specification

Isotype IgG1
Monoclonal or Polyclonal Monoclonal
Primary or Secondary Primary
Clone 2F10
Antigen Osteopontin
Concentration 5μL (0.25μg)/test
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Gene Alias bone sialoprotein I (BSP-1)
Host Species Mouse
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Conjugate eFluor 660
Format Conjugated
Quantity 25 tests
Applications Flow Cytometry
Regulatory Status RUO
Species Reactivity Human

The 2F10 monoclonal antibody recognizes human osteopontin (OPN), a secreted glycophosphoprotein expressed by multiple cell types, including leukocytes, fibroblasts, dendritic cells, macrophages, myoblasts, bone-forming cells, and epithelial cells. OPN is an extracellular matrix protein with multiple roles, including bone resorption and calcification, immune system regulation, wound healing, and tumorigenesis. Thrombin cleavage of OPN allows binding of integrin receptors, expressed by immune cells, and subsequent modulation of cell adhesion, migration, and survival. OPN is expressed in bones, teeth, placenta, blood vessels, kidney, and various tumors. Osteopontin has been identified as a potential therapeutic target in the treatment of autoimmune disease, cancer metastasis, bone mineralization diseases, and osteoporosis.