Oncostatin M Receptor Mouse anti-Human, PE, Clone: AN-V2, eBioscience™

Mouse Monoclonal Antibody

Overview
Brand: Affymetrix eBioscience

Manufacturer Part Number: 12-1303-41

Code: NEW

Additional Details:
Additional Details: Weight: 0.23750kg



Disclaimers: For Research Use Only.

Product Code. 15546876

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Description and Specification

Specification

Host Species Mouse
Quantity 25 tests
Species Reactivity Human
Storage Requirements Store at 2-8°C. Do not freeze. Light-sensitive material.
Clone AN-V2
Formulation aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Primary or Secondary Primary
Conjugate PE
Antigen Oncostatin M Receptor
Applications Flow Cytometry
Gene Alias OSMR
Regulatory Status RUO
Monoclonal or Polyclonal Monoclonal
Concentration 5μL (0.5μg)/test
Format Conjugated
Isotype IgG1

This monoclonal AN-V2 antibody reacts with the human oncostatin M (OSM) receptor. OSM, which belongs to the interleukin-6 cytokine family, is produced by T cells, activated monocytes, and dendritic cells. In humans, OSM can bind two unique receptor complexes. The type I OSM receptor is composed of the LIFR associated with gp130, and recognizes both LIF and OSM. The type II OSM receptor, which consists of gp130 and the OSMR subunit, specifically binds the cytokine, leading to activation of the JAK/STAT signaling pathway. Reports have also indicated a soluble form of the OSM receptor, which this antibody also recognizes. The OSM receptor is expressed in the bone marrow, endothelium, liver, lung, and numerous tumor cell lines.

The AN-V2 monoclonal antibody recognizes the type II (beta) OSM receptor.