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OCT3/4 Rat anti-Human, Mouse, Alexa Fluor 488, Clone: EM92, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 53-5841-80

Code : Z2

Additional Details : Weight : 0.25000kg

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Product Code. 15382040

  • £91.11 / 25µg


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For Research Use Only.


Description

Description

The EM92 monoclonal antibody reacts with mouse and human Oct3/4, encoded by the Pou5F1 gene. Oct3/4 is a POU domain-containing transcription factor that is critical for maintaining embryonic stem (ES) and induced pluripotent stem (iPS) cells in a pluripotent state, and is expressed by ES, embryonic germ cells and embryonic carcinoma cell lines. In cells of the inner cell mass (ICM), reduction of Oct3/4 expression causes dedifferentiation to trophoectoderm, whereas increased expression results in differentiation to mesoderm and primitive endoderm. Oct3/4 regulates the expression of several genes, including FGF-4, UTF1, Sox2, Fbx15, Rex1 and osteopontin through distinct mechanisms. Furthermore, Oct3/4 frequently acts synergistically with Sox2 to regulate target gene expression, as is the case with FGF-4. It has been demonstrated that Oct3/4 expression in ES cells can be negatively regulated by either treatment with retinoic acid, or by removal of leukemia-inhibitory factor (LIF).
Specifications

Specifications

OCT3/4
EM92
Alexa Fluor 488
Conjugated
Rat
25μg
Store at 2-8°C. Do not freeze. Light-sensitive material.
Monoclonal
Immunocytochemistry
0.5mg/mL
aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
OCT3, OCT4, octamer-binding transcription factor, POU5F1
IgG2a
RUO
Primary
Murine
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